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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Bioorg Med Chem. 2013 Jan 9;21(5):1123–1135. doi: 10.1016/j.bmc.2012.12.043

Figure 8.

Figure 8

Determination of cytotoxic effects on HASMCs due to presence of NO-donors at varying concentrations, using a LIVE/DEAD assay. (*) Indicates a statistically significant difference (p < 0.05) between the given compound/concentration combination and the vehicle alone. A statistically significant decrease in the percentage of LIVE cells, accompanied by no change in the percentage of DEAD cells in the presence of the same compound/concentration combination, verifies a reduction of viable HASMCs due to the inhibition of proliferation. The graphical data represents the mean ± SE of triplicate determinations, and illustrate a) the percentage of LIVE cells after exposure to A6’–A10’, b) the percentage of DEAD cells after exposure to A6’–A10’, c) the percentage of LIVE cells after exposure to B6’–B10’ and d) the percentage of DEAD cells after exposure to B6’–B10’.