Table 1.
Percent Nitrosation, Mole Percentage of Released NO, and Half-lives of NO Donors Prepared from Model Compounds. Profiles obtained in PBS Solution (Top) and in the presence of GSH (Bottom).
|
Model Compounds |
# Carbons |
% Nitrosated |
NO released (mole %) |
Apparent half-life (h) |
|---|---|---|---|---|
| A6’ | 6 | 100 | 2.34 | 105 |
| A7’ | 7 | 100 | 2.48 | 87 |
| A8’ | 8 | 100 | 2.63 | 83 |
| A9’ | 9 | 100 | 2.83 | 69 |
| A10’ | 10 | 100 | 3.00 | 60 |
| B6’ | 6 | 100 | 1.85 | 140 |
| B7’ | 7 | 100 | 2.02 | 126 |
| B8’ | 8 | 100 | 2.13 | 93 |
| B9’ | 9 | 100 | 2.32 | 80 |
| B10’ | 10 | 100 | 2.60 | 62 |
| A6’ | 6 | 100 | 0.84 | 126 |
| A9’ | 9 | 100 | 1.29 | 109 |
| B8’ | 8 | 100 | 1.32 | 123 |
| B10’ | 10 | 100 | 1.90 | 108 |