Skip to main content
. Author manuscript; available in PMC: 2014 Feb 14.
Published in final edited form as: J Med Chem. 2013 Jan 28;56(3):867–878. doi: 10.1021/jm301338q

Figure 1. Structures of heparins (A) and the polyphenolic as well as the sulfated molecules were screened against factor XIa (B).

Figure 1

Shown in A are heparins including unfractionated heparin (UFH) (Mwt ~ 15,000 Da) as well as LMWHs (Mwt ~ 4000 Da), both of which are highly heterogeneous and polydisperse mixtures of linear polysulfated polysaccharides. Shown in B are the chemical structures of the diversified library of small molecules which were screened against factor XIa including silibinin (1), sulfated silibinin (2), chlorogenic acid (3), sulfated chlorogenic acid (4), pentagalloyl glucopyranoside (5), sulfated pentagalloylglucoside (6), and tetrahydroisoquinoline–based scaffolds (7–14).