Table 2.

Mean percentage change (±S.E.M) in 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC). All samples were taken from behavioural control (non-pre-exposed) rats twice injected one week earlier with either saline or MDMA (6 mg/kg free base, i.p.) in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and amygdala. *Significant difference, p < 0.05, t-test.

	5-HT	5-HIAA	DA	DOPAC
mPFC	−31.2%* (±6.5)	−26.8% (±11.0)	+32.5% (±33.5)	+16.3% (±30.6)
NAc	−21.4% (±7.4)	−8.7% (±6.4)	+4.9% (±8.1)	+3.4% (±9.1)
Amygdala	−20.2%* (±4.2)	−5.4% (±4.4)	+24.0% (±14.6)	+31.9% (±12.8)