Table 2. (a) Association between LIPC-rs493258 and advanced AMD; (b) association between LIPC-rs10468017 and advanced AMD.
Cohort | Phenotype | N | Minor allele (A) frequency | Trend P-value | Allelic P-value | ORhet (95%CI) | ORhom (95%CI) |
---|---|---|---|---|---|---|---|
(a) | |||||||
Discovery cohort | Advanced AMD | 1626 | 0.430 | 8.76 × 10−3 | 9.63 × 10−3 | 0.79 (0.65, 0.97) | 0.73 (0.57, 0.95) |
Control | 858 | 0.468 | |||||
Replication cohort | Advanced AMD | 2159 | 0.437 | 4.48 × 10−3 | 4.48 × 10−3 | 0.88 (0.74, 1.04) | 0.74 (0.60, 0.92) |
Control | 1150 | 0.473 | |||||
Combined cohort | Advanced AMD | 3785 | 0.434 | 1.11 × 10−4 | 1.21 × 10−4 | 0.84 (0.74, 0.96) | 0.74 (0.63, 0.87) |
Control | 2008 | 0.471 | |||||
(b) | |||||||
Discovery cohort | Advanced AMD | 1617 | 0.261 | 0.047 | 0.048 | 0.90 (0.75, 1.08) | 0.72 (0.53, 1.02) |
Control | 859 | 0.288 | |||||
Replication cohort | Advanced AMD | 2159 | 0.272 | 0.015 | 0.015 | 0.88 (0.75, 1.02) | 0.74 (0.57, 0.99) |
Control | 1150 | 0.300 | |||||
Combined cohort | Advanced AMD | 3776 | 0.267 | 1.69 × 10−3 | 1.67 × 10−3 | 0.89 (0.79, 1.00) | 0.74 (0.60, 0.92) |
Control | 2009 | 0.291 |