Table 2.

Age- and multivariable-adjusted OR’s for RLS according to vascular risk factors (n=22,786)

	No RLS	RLS	Age-adjusted	Multivariable-adjusteda	P for trend
	21,076	1,710	OR (95% CI)	OR (95% CI)
History of hypertension	11,054	959	1.06 (0.95, 1.17)	0.99 (0.89, 1.11)
History of diabetes	1,753	217	1.53 (1.31, 1.78)	1.41 (1.21, 1.65)
History of cholesterol ≥ 240mg/dl	11,013	955	1.13 (1.03, 1.25)	1.11 (1.01, 1.23)
BMI categories					0.01
<23	3,883	312	1.00	1.00
23–24.9	5,051	354	0.90 (0.77, 1.06)	0.90 (0.77, 1.05)
25–29.9	9,701	806	1.09 (0.95, 1.25)	1.06 (0.92, 1.21)
30–34.9	1,997	192	1.30 (1.07, 1.57)	1.20 (0.99, 1.45)
≥35	444	46	1.42 (1.03, 1.97)	1.24 (0.89, 1.73)
Smoking Status
Never	11,160	876	1.00	1.00
Past	9,335	788	1.02 (0.92, 1.13)	1.02 (0.92, 1.14)
Current	581	46	1.00 (0.74, 1.36)	0.99 (0.72, 1.34)
Alcohol consumption					<0.01
Rarely/never	3,827	364	1.00	1.00
1–3 drinks per month	2,550	214	0.92 (0.77, 1.10)	0.92 (0.77, 1.09)
1–6 drinks per week	7,724	619	0.88 (0.77, 1.00)	0.90 (0.78, 1.03)
≥ 1 drink/day	6,975	513	0.77 (0.67, 0.89)	0.80 (0.69, 0.92)
Exercise					0.01
Rarely/never	7,461	679	1.00	1.00
≤ 1/week	508	41	0.97 (0.70, 1.35)	0.98 (0.70, 1.36)
2–4 times/week	9,242	734	0.92 (0.83, 1.03)	0.96 (0.86, 1.08)
5–7 times/week	3,865	256	0.75 (0.65, 0.87)	0.78(0.67, 0.91)
Parental history of myocardial infarction	2,483	190	0.96 (0.82, 1.12)	0.95 (0.81, 1.12)

^aMultivariable models include all vascular risk factors and were adjusted for age, randomized aspirin assignments.