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Blood levels of S1P and dihydro-S1P are reduced, whereas very long chain ceramides are increased in Spns2-knockout mice. Lipids were extracted from plasma (A) and whole blood (B, C) from wild-type (WT) and Spns2-knockout mice and dihydrosphingosine, dihydro-S1P, sphingosine, and S1P (A, B), and ceramide species (C) were determined by LC-ESI-MS/MS. Numbers indicate chain length followed by the number of double bonds in the fatty acid. *P < 0.05.
