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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Mol Genet Metab. 2012 Mar 23;106(2):189–195. doi: 10.1016/j.ymgme.2012.03.009

Fig. 6.

Fig. 6

Cytokine responses to the immunodominant epitopes upon ERT in Pompe mice. GAA−/− 129SVE mice received 3 weekly intravenous doses of rhGAA (20 mg/kg) followed by splenocyte assays. A. Representative examples of well images IL-4 ELISpot assay after stimulation with peptide 19, 29, or 83, or GAA protein, or SEB, or mock controls. B. Average frequencies of IL-4 spot forming units for 4 mice assayed individually (duplicate stimulations). C. Average values (± SD) for the group of 4 animals. Peptide 83 showed statistically significant responses compared to mock stimulation. D. Average frequencies of IL-17 spot forming units for 3 mice assayed individually (duplicate stimulations). E. Average values (± SD) for the group of 3 animals. Peptide 19 showed statistically significant responses compared to mock stimulation. F. Average values (± SD) for 4 animals assayed by IFN-γ ELISpot.