Fig. 2.

Lesion size assessment and gross pathology. A clear difference between sham, partial and total MCAO was observed at day 1 following MCAO in T2 TSE MRI scans (a and b). However, no initial differences in lesion size were observed between total MCAO without or with BM MNC administration. At day 49, lesion surface measurement revealed smaller lesion sizes in partial MCAO and BM MNC subjects as compared to total MCAO (c). Slight leptomeningeal alterations in the area of trepanation were regularly observed in sham-treated animals (d, white dotted line), being much smaller than a total MCAO lesion (c, p < 0.01, significance given in brackets). Measurement of ventricular expansion revealed similar findings (e and f). */**p < 0.05/0.01 versus total MCAO