Table 4.
Relative risk (95% CI) for quintiles of estrogen pattern score and risk of post-menopausal breast cancer
| Q1 | Q2 | Q3 | Q4 | Q5 | P trend | |
|---|---|---|---|---|---|---|
| Total breast cancer | ||||||
| No. of cases | 1028 | 910 | 933 | 885 | 840 | |
| Age & energy adjusted | 1 | 0.90 (0.82, 0.98) | 0.95 (0.87, 1.04) | 0.95 (0.87, 1.05) | 0.96 (0.87, 1.06) | 0.71 |
| Multivariate adjusted* | 1 | 0.88 (0.80, 0.96) | 0.93 (0.85, 1.02) | 0.94 (0.86, 1.05) | 0.95 (0.86, 1.05) | 0.47 |
| ER+ tumors | ||||||
| No. of cases | 664 | 610 | 588 | 551 | 525 | |
| Age & energy adjusted | 1 | 0.93 (0.83, 1.04) | 0.93 (0.83, 1.04) | 0.93 (0.83, 1.04) | 0.94 (0.83, 1.06) | 0.37 |
| Multivariate adjusted* | 1 | 0.92 (0.82, 1.03) | 0.92 (0.82, 1.03) | 0.92 (0.82, 1.03) | 0.94 (0.83, 1.07) | 0.36 |
| ER− tumors | ||||||
| No. of cases | 132 | 138 | 155 | 137 | 127 | |
| Age & energy adjusted | 1 | 1.06 (0.84, 1.35) | 1.21 (0.96, 1.52) | 1.10 (0.86, 1.40) | 1.04 (0.81, 1.35) | 0.69 |
| Multivariate adjusted* | 1 | 1.04 (0.82, 1.32) | 1.18 (0.93, 1.50) | 1.08 (0.84, 1.38) | 1.03 (0.79, 1.34) | 0.73 |
*
adjusted for age (in months), energy intake (quintiles), multivitamin use (yes/no), alcohol intake (4 categories), weight change since age 18 (8 categories), BMI at age 18 (5 categories), family history (yes/no), history of benign breast disease (yes/no), physical activity (5 categories), postmenopausal hormone use (12 categories)