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. Author manuscript; available in PMC: 2013 Oct 31.
Published in final edited form as: J Am Chem Soc. 2012 Oct 18;134(43):17912–17921. doi: 10.1021/ja212080f

Figure 1.

Figure 1

Structures of Scaffold I and II peptides. (A) Variants LL1 through AL1 were prepared to examine scaffold I. (B) Molecular structures of Hfl and Ati (or single-letter code “@”). (C) Variants LL2 through GG2 were prepared to examine scaffold II. Substitutions were made at positions X1 and X2 (in red). For scaffold II, additional control folded and unfolded peptides were prepared with the sequences Val-Ati-Thr and Cyc = Val-DPro-Ala-Val-Ati-Val-DPro-Ala-Val-Val (cyclic), respectively.