Table 1.
Red blood cell fatty acids [median (IQR)] as predictors of 2 year mortality, alone and adjusted for GRACE score
| Status at 2 years | Fatty Acids Alone | With GRACE Score | ||||
|---|---|---|---|---|---|---|
| RBC Fatty Acid | Dead n = 135 | Alive n = 1009 | Hazard Ratio Unadjusted | Prop Hazard p-value Unadjusted | Hazard Ratio Adjusted | Prop Hazard p-value Adjusted |
| Myristic | 0.188 (0.148, 0.264) | 0.222 (0.148, 0.312) | 0.273 (0.073, 1.018) | 0.0531 | 0.443 (0.119, 1.64) | 0.2225 |
| Palmitic | 20.119 (18.510, 21.451) | 20.004 (18.477, 21.380) | 0.989 (0.923, 1.059) | 0.7504 | 0.992 (0.923, 1.066) | 0.8207 |
| Palmitoleic | 0.421 (0.300, 0.604) | 0.471 (0.331, 0.667) | 0.817 (0.596, 1.12) | 0.2097 | 0.861 (0.647, 1.146) | 0.3052 |
| Stearic | 15.558 (14.517, 16.725) | 15.815 (14.785, 17.002) | 0.942 (0.863, 1.028) | 0.1769 | 0.96 (0.882, 1.045) | 0.3455 |
| Oleic | 14.761 (13.621, 16.169) | 14.592 (13.379, 15.816) | 1.06 (0.992, 1.134) | 0.0869 | 1.028 (0.959, 1.102) | 0.4437 |
| Linoleic | 12.879 (11.789, 13.826) | 13.287 (11.803, 14.661) | 0.91 (0.842, 0.983) | 0.0169 | 0.957 (0.883, 1.037) | 0.2795 |
| γ-Linolenic | 0.080 (0.053, 0.116) | 0.091 (0.061, 0.132) | 2.158 (0.446, 10.434) | 0.3386 | 2.901 (0.705, 11.942) | 0.1401 |
| α-Linolenic | 0.159 (0.116, 0.191) | 0.158 (0.118, 0.215) | 1.123 (0.283, 4.456) | 0.8694 | 1.025 (0.224, 4.693) | 0.9746 |
| Eicosenoic | 0.148 (0.110, 0.214) | 0.135 (0.102, 0.186) | 2.38 (0.748, 7.567) | 0.1418 | 1.173 (0.318, 4.32) | 0.8108 |
| Eicosadienoic | 0.292 (0.217, 0.376) | 0.262 (0.211, 0.345) | 1.217 (0.756, 1.957) | 0.4190 | 1.334 (0.8, 2.224) | 0.2686 |
| Dihomo-γ-linolenic | 1.562 (1.284, 1.809) | 1.639 (1.388, 1.996) | 0.51 (0.346, 0.752) | 0.0007 | 0.678 (0.455, 1.008) | 0.0547 |
| Arachidonic | 20.195 (18.675, 22.039) | 19.959 (18.340, 21.470) | 1.07 (0.999, 1.146) | 0.0543 | 1.041 (0.973, 1.113) | 0.2486 |
| Eicosapentaenoic | 0.552 (0.382, 0.746) | 0.607 (0.408, 0.858) | 0.508 (0.302, 0.854) | 0.0106 | 0.524 (0.312, 0.88) | 0.0145 |
| Docosatetraenoic | 4.164 (3.480, 4.669) | 3.942 (3.329, 4.497) | 1.13 (0.99, 1.29) | 0.0697 | 1.109 (0.957, 1.285) | 0.1679 |
| Docosapentaenoic n-6 | 0.835 (0.654, 1.004) | 0.767 (0.616, 0.942) | 1.599 (1.038, 2.465) | 0.0334 | 2.002 (1.257, 3.187) | 0.0035 |
| Docosapentaenoic n-3 | 2.793 (2.368, 3.298) | 2.824 (2.400, 3.254) | 0.971 (0.772, 1.222) | 0.8029 | 1.041 (0.825, 1.313) | 0.7357 |
| Docosahexaenoic | 4.364 (3.469, 5.442) | 4.267 (3.445, 5.306) | 1.073 (0.958, 1.201) | 0.2246 | 1.004 (0.889, 1.134) | 0.9438 |
| Omega-3 Index* | 4.921 (3.994, 6.164) | 4.859 (3.981, 6.055) | 1.021 (0.924, 1.13) | 0.6788 | 0.968 (0.868, 1.08) | 0.5643 |
| n3/n6 ratio | 0.289 (0.239, 0.346) | 0.286 (0.245, 0.349) | 0.701 (0.123, 3.994) | 0.6887 | 0.479 (0.078, 2.953) | 0.4279 |
| n3HUFA/total HUFA† | 0.224 (0.193, 0.257) | 0.222 (0.197, 0.259) | 0.464 (0.018, 12.235) | 0.6455 | 0.214 (0.007, 6.402) | 0.3741 |
*
sum of eicosapentaenoic and docosahexaenoic acids;
†
highly unsaturated fatty acids, i.e., >C18 and >2 double bonds.