Table 2.

Model parameters.

Model parameter	Symbol	Value (range)	Reference
Oxygen tension
Krogh diffusion coefficient	Dk	2.5 μm2 mlO2/ml/min/mmHg	Vaupel (1979)
Oxygen consumption rate	Qmax	0.5 ml O2/100 g/min (0.2–4 ml O2/100 g/min)	Vaupel et al (1989)
pO2 at 50% consumption rate	p50	0.5 mmHg	Gnaiger et al (1998)
Vascular pO2	p0	60 mmHg
Capillary radius	rc	10 μm (2–100 μm)	Konerding et al (1999)
Vessel matrix
Simulated microvessel density	sMVD	Variable
Normalized microvessel density	nMVD	Variable
Box size	BS	Dependent on sMVD
First angle for capillary sprouting	α	Based on probability distribution	Op Den Bujis et al (2006)
Second angle for capillary sprouting	β	Sampled uniformly from 0–2π
Average vessel length	SL	Capillaries: 120 μm Large vessels: 720 μm (diameter: length = 1:6)	Less et al (1991)
Imaged vessel radius	ri	>125 μm	Refer to the imaging section
Large vessel radius	rl	60 μm
Voxel resolution used for the simulated data		20 μm