Table 1.
Baseline characteristics according to RLS status (n=30,262)
| No RLS | RLS | p-value | |
|---|---|---|---|
| n=26,638 | n=3,624 | ||
| Demographic information | |||
| Mean age, yrs (SD) | 63.6 (6.9) | 63.6 (6.9) | 0.86 |
| Ethnicity, % | |||
| White | 25,138 (95.1) | 3,512 (97.5) | <0.01 |
| Geographic location,% | |||
| Northeast | 5,216 (19.6) | 623 (17.2) | |
| Southeast | 6,093 (22.9) | 859 (23.7) | <0.01 |
| Midwest | 9,553 (35.9) | 1,359 (37.5) | |
| West | 5,734 (21.6) | 780 (21.5) | |
| Prevalent CVD events, % | |||
| Major CVD | 406 (1.5) | 61 (1.7) | 0.47 |
| Coronary revascularization | 398 (1.5) | 88 (2.4) | <0.01 |
| Myocardial infarction | 194 (0.7) | 40 (1.1) | 0.02 |
| Stroke | 215 (0.8) | 22 (0.6) | 0.20 |
| CVD risk factors, % | |||
| History of hypertension | 12,721 (47.8) | 1,880 (51.9) | <0.01 |
| History of diabetes | 1,890 (7.1) | 340 (9.4) | <0.01 |
| History of cholesterol ≥ 240mg/dl | 14,317 (53.8) | 2,137 (59.0) | <0.01 |
| BMI categories (kg/m2) | |||
| <23 | 6,250 (23.5) | 735 (20.3) | |
| 23–24.9 | 4,807 (18.1) | 612 (16.9) | |
| 25–29.9 | 9,120 (34.2) | 1,249 (34.5) | <0.01 |
| 30–34.9 | 4,221 (15.9) | 634 (17.5) | |
| ≥35 | 2,240 (8.4) | 394 (10.9) | |
| Smoking Status | |||
| Never | 13,800 (51.8) | 1,694 (46.7) | |
| Past | 10,673 (40.1) | 1,589 (43.9) | <0.01 |
| Current < 15 cigarettes/day | 1,084 (4.1) | 154 (4.3) | |
| Current ≥ 15 cigarettes/day | 1,081 (4.1) | 187 (5.2) | |
| Alcohol consumption | |||
| Rarely/never | 11,412 (42.8) | 1,645 (45.4) | |
| 1–3 drinks per month | 3,096 (11.6) | 411 (11.3) | 0.03 |
| 1–6 drinks per week | 9,065 (34.0) | 1,170 (32.3) | |
| ≥ 1 drink/day | 3,065 (11.5) | 398 (11.0) | |
| Exercise | |||
| Rarely/never | 10,066 (37.8) | 1,439 (39.7) | |
| <1/week | 5,287 (19.9) | 753 (20.8) | <0.01 |
| 1–3 times/week | 8,313 (31.2) | 1,101 (30.4) | |
| ≥ 4 times/week | 2,972 (11.2) | 331 (9.1) | |
| Parental history of myocardial infarction | 4,571 (17.2) | 692 (19.1) | <0.01 |
| Other covariates, % | |||
| History of migraine during follow-up | 5,645 (21.2) | 962 (26.6) | <0.01 |
| History of depression | 3,194 (12.0) | 729 (20.1) | <0.01 |
| History of Parkinson's disease | 111 (0.4) | 19 (0.5) | 0.35 |
| Iron supplementation use | 1,049 (4.0) | 126 (3.5) | 0.17 |
Percentages may not add up to 100 because of missing values or rounding