Table 2.

Age- and multivariable-adjusted^* OR's (95% CI) for RLS according to vascular risk factors (n=30,262)

	No RLS	RLS	Age-adjusted	Multivariable-adjusted*	P for trend
	26,638	3,624	OR (95% CI)	OR (95% CI)
History of hypertension	12,721	1,880	1.19 (1.11, 1.28)	1.06 (0.98, 1.15)
History of diabetes	1,890	340	1.36 (1.20, 1.53)	1.19 (1.04, 1.35)
History of cholesterol ≥ 240mg/dl	14,317	2,137	1.24 (1.16, 1.33)	1.17 (1.09, 1.26)
BMI categories					<0.01
<23	6,250	735	1.00	1.00
23–24.9	4,807	612	1.08 (0.97, 1.21)	1.06 (0.94, 1.19)
25–29.9	9,120	1,249	1.17 (1.06, 1.28)	1.11 (1.00, 1.22)
30–34.9	4,221	634	1.28 (1.14, 1.43)	1.18 (1.04, 1.33)
>35	2,240	394	1.50 (1.32, 1.72)	1.35 (1.17, 1.56)
Smoking Status
Never	13,800	1,694	1.00	1.00
Past	10,673	1,589	1.21 (1.13, 1.31)	1.22 (1.13, 1.31)
Current < 15 cigarettes/day	1,084	154	1.16 (0.97, 1.38)	1.19 (1.00, 1.42)
Current ≥ 15 cigarettes/day	1,081	187	1.41 (1.20, 1.66)	1.41 (1.19, 1.66)
Alcohol consumption
Rarely/never	11,412	1,645	1.00	1.00
1–3 drinks per month	3,096	411	0.92 (0.82, 1.03)	0.93 (0.83, 1.04)	0.04
1–6 drinks per week	9,065	1,170	0.89 (0.83, 0.97)	0.92 (0.84, 1.00)
≥ 1 drink/day	3,065	398	0.90 (0.80, 1.01)	0.92 (0.81, 1.04)
Exercise
Rarely/never	10,066	1,439	1.00	1.00
<1/week	5,287	753	1.00 (0.91, 1.09)	1.02 (0.93, 1.12)	0.03
1–3 times/week	8,313	1,101	0.93 (0.85, 1.01)	0.98 (0.90, 1.06)
≥ 4 times/week	2,972	331	0.78 (0.69, 0.88)	0.84 (0.74, 0.95)
Parental history of myocardial infarction	4,571	692	1.14 (1.04, 1.25)	1.10 (1.00, 1.20)

^*Multivariable models include all vascular risk factors and were adjusted for age, randomized aspirin assignment, postmenopausal status, postmenopausal hormone use, oral contraceptive use