Appendix Table 1.

sensitivity analysis^*. Age- and multivariable-adjusted^† OR's (95% CI) for RLS according to vascular risk factors (n=28,015)

	No RLS	RLS	Age-adjusted	Multivariable- adjusted
	24,732	3,283	OR (95% CI)	OR (95% CI)
History of hypertension	11,569	1,652	1.16 (1.08, 1.25)	1.04 (0.96, 1.13)
History of diabetes	1,610	268	1.28 (1.12, 1.46)	1.13 (0.98, 1.30)
History of cholesterol ≥ 240mg/dl	13,106	1,908	1.24 (1.15, 1.33)	1.17 (1.08, 1.26)
BMI categories
<23	5,864	679	1.00	1.00
23–24.9	4,524	559	1.07 (0.95, 1.20)	1.04 (0.93, 1.18)
25–29.9	8,480	1,148	1.17 (1.06, 1.29)	1.12 (1.01, 1.24)
30–34.9	3,856	558	1.25 (1.11, 1.41)	1.16 (1.02, 1.32)
≥35	2,008	339	1.46 (1.27, 1.69)	1.34 (1.15, 1.56)
Smoking Status
Never	12,901	1,550	1.00	1.00
Past	9,868	1,441	1.22 (1.13, 1.31)	1.22 (1.13, 1.32)
Current < 15 cigarettes/day	985	139	1.17 (0.98, 1.41)	1.21 (1.00, 1.46)
Current ≥ 15 cigarettes/day	978	153	1.30 (1.09, 1.56)	1.31 (1.09, 1.57)
Alcohol consumption
Rarely/never	10,397	1,449	1.00	1.00
1–3 drinks per month	2,883	384	0.96 (0.85, 1.08)	0.96 (0.85, 1.08)
1–6 drinks per week	8,553	1,087	0.91 (0.84, 0.99)	0.92 (0.84, 1.00)
≥1 drink/day	2,899	363	0.90 (0.80, 1.02)	0.90 (0.80, 1.03)
Exercise
Rarely/never	9,258	1,285	1.00	1.00
<1/week	4,894	673	0.99 (0.90, 1.09)	1.01 (0.91, 1.12)
1–3 times/week	7,797	1,017	0.94 (0.86, 1.03)	0.98 (0.90, 1.07)
≥ 4 times/week	2,783	308	0.80 (0.70, 0.91)	0.85 (0.74, 0.97)
Parental history of myocardial infarction	4,207	625	1.15 (1.05, 1.26)	1.11 (1.01, 1.22)

^*2,247 women with a history of polyneuropathy, kidney disease/kidney failure, liver disease, rheumatoid arthritis, intermittent claudication or who underwent peripheral artery disease surgery were excluded.

^†Multivariable models include all vascular risk factors and were adjusted for age, randomized aspirin assignment, postmenopausal status, postmenopausal hormone use, oral contraceptive use.