Appendix Table 2.

sensitivity analysis^* Age- und multivariable-adjusted^† OR's (95% CI) for RLS according to prevalent CVD events (n=28,015)

	No RLS history	Any history of RLS
	n=24,732	n=3,283
Major CVD event	n=349	n=47
Age-adjusted	1.00	1.02 (0.75, 1.38)
Multivariable-adjusted	1.00	0.91 (0.67, 1.24)
Coronary revascularization	n=329	n=60
Age-adjusted	1.00	1.39 (1.05, 1.83)
Multivariable-adjusted	1.00	1.20 (0.91, 1.60)
Myocardial infarction	n=163	n=27
Age-adjusted	1.00	1.25 (0.83, 1.89)
Multivariable-adjusted	1.00	1.10 (0.73, 1.66)
Stroke	n=188	n=20
Age-adjusted	1.00	0.80 (0.50, 1.27)
Multivariable-adjusted	1.00	0.73 (0.46, 1.16)

^*2,247 women with a history of polyneuropathy, kidney disease/kidney failure, liver disease, rheumatoid arthritis, intermittent claudication or who underwent peripheral artery disease surgery were excluded.

^†Multivariable models were adjusted for age, randomized aspirin assignment, parental history of myocardial infarction, history of diabetes, body mass index, smoking status, alcohol consumption, history of hypertension, exercise, hypercholesterolemia, history of depression, postmenopausal hormone use, postmenopausal status, and oral contraceptive use