Table 3.
Patients characteristics at enrollment.
| Study | ACCESS [27] | PRoFESS [28]* | SCATS [29] |
|---|---|---|---|
| treatment/placebo | treatment/placebo | treatment/placebo | |
| Number of patients | 173/166 | 647/713 | 1017/1012 |
| Age | 68.3 (9.3)/67.8 (9.4) | 66.8 (8.8)/67.1 (9.2) | 70.8 (11.2)/71.0 (11.0) |
| Male (%) | 86 (49.7)/86 (51.8) | 420 (64.9)/464 (65.1) | 612 (60.2)/564 (55.7) |
| Clinical history | |||
| Previous stroke/TIA | NA | 160 (24.7)/184 (25.8) | 252 (24.8)/204 (20.2) |
| Atrial fibrillation | NA | 10 (1.6)/14 (2.0) | 190 (18.7)/186 (18.4) |
| Hypertension | NA | 453 (70.0)/503 (70.6) | 676 (66.5)/670 (66.2) |
| Diabetes mellitus | 67 (38.7)/58 (35.0) | 176 (27.2)/198 (27.8) | 163 (16.0)/157 (15.5) |
| Hyperlipidemia | 74 (42.8)/75 (45.2) | 264 (40.8)/283 (39.7) | NA |
| Ischemic heart disease | 38 (22)/32 (19.3) | 95 (14.7)/104 (14.6) | NA |
| Time from stroke (hours) | 29.9/29.7 | 57.6 (16.8)/57.6 (16.8) | 17.6 (8.1)/17.9 (8.1) |
| Blood pressure (mmHg) | |||
| Systolic | 188 (20.9)/190 (19.7) | 146 (16.2)/147 (16.3) | 171.2 (19.0)/171.6 (19.2) |
| Diastolic | 99 (14.9)/99 (13.0) | 84 (10.1)/84 (10.2) | 90.3 (13.9)/90.6 (14.2) |
| Clinical severity | 60.0 (30.2)/64.1 (27.5) at BI | 2.9 (2.8)/3.1 (2.9) at NIHSS | 40.6 (12.3)/40.5 (12.6) at SSS |
*In the PRoFESS trial a subgroup analysis has been considered.
Data are n (%) or mean (SD). NA: not assessed. BI: Barthel Index; mRS: modified ranking scale; NIHSS: National Institutes of Health Stroke Scale; SSS: Scandinavian stroke scale.