Table 1.

Results from the reaction shown in Equation 1 as a function of ligand and applied electrochemical potential. The reported yields were obtained by quantitative LC-MS analysis of aliquots removed at the indicated times, and are the average of three independent runs (error ±5%).

Entry	Reductant	Copper	Ligand	% Yield 15 min	% Yield 60 min
1	E, none [a]	None	none	1	1
2	none	CuSO4	none	3	3
3	E, none [a]	CuSO4	any	3	3
4	Ascorbate [b]	CuSO4	none	4	8
5	Ascorbate [b]	CuSO4	2	82	97
6	Ascorbate [b]	CuSO4	3	68	68
7	Ascorbate [b]	CuSO4	4	98	99
8	E, -50mV	CuSO4	none	3	5
9	E, -200mV	CuSO4	none	4	8
10	E, -50mV	CuSO4	2	58	84
11	E, -200mV	CuSO4	3	98	99
12	E, -200mV	CuSO4	4	6	42

^[a]In the electrochemical cell with electrodes disconnected.

^[b]1 mM sodium ascorbate.