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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Future Med Chem. 2012 Dec;4(18):2241–2249. doi: 10.4155/fmc.12.174

Figure 3. Hybrid drugs are intended to act at multiple targets, in this case represented schematically by ‘i’ and ‘ii’.

Figure 3

(A) At the single-molecule level, a conventional hybrid cannot act simultaneously at both targets. (B) In a fragmenting hybrid, action at one target (e.g., ii) is made contingent on prior action at the other (e.g., i).