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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Future Med Chem. 2012 Dec;4(18):2241–2249. doi: 10.4155/fmc.12.174

Figure 4. Two examples of fragmenting hybrids.

Figure 4

(A) Early example of a fragmenting hybrid [18]. Iron(II)-promoted fragmentation of endoperoxide 4 produces a cytotoxic carbon-centered radical species (5) while simultaneously leading to hybrid fragmentation and release of a chalcone partner drug (6). (B) Fragmenting hybrid systems 7 described herein [17]. Iron(II)-promoted fragmentation of trioxolane 7 produces a carbon-centered radical (8) while simultaneously unveiling a ketone that undergoes β-elimination to release a partner drug (9).