. Author manuscript; available in PMC: 2013 Oct 1.

Published in final edited form as: Future Med Chem. 2012 Dec;4(18):2241–2249. doi: 10.4155/fmc.12.174

Table 1.

Antimalarial and biochemical activities of compounds 13–22.

Compound	W2 Plasmodium falciparum EC₅₀ (µM)	D10 P. falciparum EC₅₀ (µM)	Falcipain-2 IC₅₀(µM)	DPAP-1 IC₅₀(µM)
13	0.014 (0.002)	0.029 (0.013)^†	n.d.	>10^†
14	0.040 (0.001)	n.d.	n.d.	n.d.
15	0.024	n.d.	n.d.	n.d.
16	0.049 (0.004)	n.d.	n.d.	n.d.
17	0.063 (0.029)	n.d.	n.d.	n.d.
18	0.180 (0.002)	n.d.	1.02 (0.02)	n.d.
19	0.60 (0.07)	n.d.	>50	n.d.
20	n.d.	0.0052 (0.0004)^†	n.d.	0.070 (0.013)^†
21	n.d.	0.0040 (0.0002)^†	n.d.	10^†
22	n.d.	0.052 (0.007)^†	n.d.	>10^†

Standard deviations are provided in parentheses.

^†

Data taken from [17].

n.d.: Not determined.