Table 1.

Clinical characteristics of the patients with adrenal insufficiency, versus control group

	All	No adrenal insufficiency	Adrenal insufficiency	Pvalue
Number of patients	281	249	32
Women	132 (47.0)	113 (45.4)	19 (59.4)	0.19
Age (mean)	67 ± 16	68 ± 16	63 ± 15	0.10
Symptoms
Abdominal pain	35 (12.5)	30 (12.1)	5 (15.6)	0.57
Hypotension symptoms	12 (4.3)	12 (4.8)	0 (0.0)	0.37
Fatigue	48 (17.1)	40 (16.1)	8 (25.0)	0.31
Glucocorticoid withdrawal	53 (18.9)	36 (14.5)	17 (53.1)	<0.001
Nausea	21 (7.5)	16 (6.4)	5 (15.6)	0.07
Generalized weakness	40 (14.2)	33 (13.3)	7 (21.9)	0.19
Signs
Eosinophilia	2 (0.7)	1 (0.4)	1 (3.1)	0.22
Low blood pressure	141 (50.2)	125 (50.2)	16 (50.0)	0.87
Vitiligo	2 (0.7)	1 (0.4)	1 (3.1)	0.22
Biological markers
Acidosis	7 (2.5)	7 (2.8)	0 (0.0)	1.00
Hypercalcaemia	10 (3.6)	10 (4.0)	0 (0.0)	0.61
Hyperkaliemia	35 (12.5)	28 (11.2)	7 (21.9)	0.09
Hyponatremia	87 (31.0)	80 (32.1)	7 (21.9)	0.31

Definitions: low blood pressure (<100 mmHg systolic and/or <50 mmHg diastolic blood pressure), vitiligo and/or skin changes. Biological markers collected were: hyperkalemia (>5 mmol/l), hyponatremia (<135 mmol/l), acidosis (pH <7.35), hypercalcaemia (total and ionized, corrected calcium >2.5 mmol/l) and eosinophilia (>0.5 G/l). Results are expressed as number of patients and (percentage). Statistical analysis performed using chi-square or Fischer’s exact test.