Table 2.
Univariate and multivariate analysis including acute kidney injury to determine predictors of mortality
|
Variable |
Unadjusted |
P-value |
Adjusted |
P-value |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Age (years) |
1.01 (0.9-1.03) |
0.110 |
|
|
| Gender (Male) |
1.3 (0.8-2.1) |
0.322 |
|
|
| Race (Caucasian) |
0.9 (0.6-1.6) |
0.962 |
|
|
| Comorbidity | ||||
| Diabetes mellitus |
1.4 (0.6-3.3) |
0.413 |
|
|
| Hypertension |
1.1 (0.5-2.1) |
0.848 |
|
|
| CVD |
1.2 (0.5-3.0) |
0.651 |
|
|
| CKD |
2.7 (1.1-6.6) |
0.034 |
2 (0.8-5.2) |
0.147 |
| Chronic lung disease |
0.9 (0.2-4.0) |
0.968 |
|
|
| Cirrhosis |
0.6 (0.2-1.5) |
0.295 |
|
|
| HCV coinfection |
1.5 (0.9-2.3) |
0.074 |
|
|
| HBV coinfection |
1.5 (0.7-3.1) |
0.273 |
|
|
| Cancer |
2.5 (1.3-4.6) |
0.004 |
2.1 (1.1-4) |
0.017 |
| HIV-related characteristics | ||||
| Type of HIV (HIV-1) |
2.1 (0.5-8.4) |
0.312 |
|
|
| HAART |
1.1 (0.6-1.6) |
0.963 |
|
|
| CD4 count < 200 cells/mm3 |
1.6 (1.1-2.6) |
0.039 |
1.4 (0.8-2.4) |
0.197 |
| Viral load detectable |
1.6 (0.8-3.0) |
0.196 |
|
|
| AIDS |
1.8 (1.1-3.0) |
0.023 |
1.3 (0.8-2.4) |
0.311 |
| Sepsis |
1.6 (0.8-2.9) |
0.176 |
|
|
| ICU admission |
0.5 (0.1-2) |
0.317 |
|
|
| AKI | 1.9 (1.1-3.3) | 0.013 | 1.7 (1.1-3) | 0.049 |
AIDS- acquired immunodeficiency syndrome. AKI- acute kidney injury. CI- confidence interval. CKD- chronic kidney disease, considered whenever baseline glomerular filtration rate was <60 mL/min/1.73m2. CVD- cardiovascular disease. HAART- highly active antiretroviral therapy. HBV- hepatitis B virus. HCV- hepatitis C virus. HIV- human immunodeficiency virus. HR- hazard ratio. ICU- intensive care unit.