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. 2013 Jan 7;110(7):2647–2652. doi: 10.1073/pnas.1213364110

Fig. 1.

Fig. 1.

HDAC3 inhibition enhances the rate and persistence of extinction of cocaine-CPP. (A) Schematic of cocaine-CPP training and extinction. (B) Treatment with RGFP966 (10 mg/kg) after posttest 1 significantly reduced cocaine-CPP, and the effect was maintained in subsequent CPP tests. Vehicle, n = 12; RGFP966 3 mg/kg, n = 12; RGFP966 10 mg/kg, n = 12. (C) Mice treated with RGFP966 (10 mg/kg) during extinction consolidation did not reinstate cocaine-seeking behavior; Vehicle, n = 8; RGFP966 3 mg/kg, n = 7; RGFP966 10 mg/kg, n = 8. Data are expressed as mean ± SEM. †Significantly different from 0. *Significantly different from vehicle; P < 0.05.