Fig. 2.

HDAC3 inhibition simultaneously reduces drug-seeking behavior and enhances memory. (A) Schematic of cocaine-CPP training and extinction, followed in parallel with OLM training. RGFP966 was administered immediately after extinction training, 1 h before OLM training in the same mice. Vehicle, n = 6; RGFP966 10 mg/kg; n = 6. (B) RGFP966 administered immediately after a nonreinforced exposure resulted in loss of CPP the next day. (C) RGFP966 treatment resulted in significantly enhanced object location memory. Data are expressed as mean ± SEM. *Significantly different from vehicle; P < 0.05.