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. Author manuscript; available in PMC: 2013 May 22.
Published in final edited form as: Annu Rev Biomed Eng. 2012 May 22;14:431–455. doi: 10.1146/annurev-bioeng-071910-124638

Table 1.

Molecular associations between Sun and Nesprin proteins of the LINC complex

Nucleoplasmic
partners/function		 SUN
domain
protein		 KASH
domain
protein		 Cytoplasmic
partners/function
Anchorage between lamina and INM
Nuclear positioning (158, 159)
Maintenance of perinuclear
space
Anchorage of telomeres
(160, 161)		 Sun1
and
Sun2		 Nesprin 1 and nesprin
2
(multiple variants including
GIANT isoforms)		 Anchorage between ONM and actin
 filaments in cytoskeleton
Nesprin 2 links nucleus to MTOC and
 kinesin-1 (162)
Nesprin 3 Anchorage to intermediate filaments via
plectin adaptor protein (60)
Postmeiotic,
sperm-specific isoforms (163)		 Sun1rη and Sun3 Nesprin 1 and
nesprin 3		 Manchette microtubules
Sperm-specific isoform (164) Spag 4 and Spag 4L/2 Unknown Unknown
Nuclear positioning Unknown Nesprin 4 Connects to kinesin-1 (165)

Abbreviations: INM, inner nuclear membrane; KASH, Klarsicht/ANC-1/Syne-1 homology; LINC, linker of the nucleoskeleton and cytoskeleton; MTOC, microtubule organizing center; ONM, outer nuclear membrane; Sun, Sad1 and UNC84; Spag4, sperm associated antigen