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Onset and worsening of bone pain after drug reduction (compared to t0)
| Bone pain | t3 | t6 | t9 | t12 |
|---|---|---|---|---|
| Onset | ||||
| Overall | 5/20 | 6/19 | 4/18 | 4/17 |
| Adults | 5/18 | 6/17 | 4/16 | 4/15 |
| Children | 0/2 | 0/2 | 0/2 | 0/2 |
| Worsening | ||||
| Overall | 8/13 | 7/13 | 3/10 | 1/9 |
| Adults | 8/11 | 6/12 | 2/9 | 1/9 |
| Children | 0/2 | 1/1 | 1/1 | 0/0 |
| Onset or worsening | ||||
| Overall | 13/33 | 13/32 | 7/28 | 5/26 |
| Adults | 13/29 | 12/29 | 6/25 | 5/24 |
| Children | 0/4 | 1/3 | 1/3 | 0/2 |
