Table 2.
Results of the logistic regression analyses assessing the diagnostic value of Phe/Tyr ratio 2 h after Phe loading and neopterin concentration in urine
| Area under the ROC curve | Phe/Tyr 2nd hour | Neopterino | Phe/Tyr 2nd hour + Neopterino | |||
|---|---|---|---|---|---|---|
| Age | ||||||
| <15 years (n = 23) | ≥15 years (n = 25) | <15 years (n = 59) | ≥15 years (n = 42) | <15 years (n = 23) | ≥15 years (n = 25) | |
| Se % | 66.7 | 83.3 | 75.0 | 42.9 | 100.0 | 100.0 |
| Sp % | 100.0 | 94.7 | 98.2 | 94.3 | 100.0 | 100.0 |
| PPV % | 100.0 | 83.3 | 75.0 | 60.0 | 100.0 | 100.0 |
| NPV % | 95.2 | 94.7 | 98.2 | 89.2 | 100.0 | 100.0 |
| Correctly classified % | 95.7 | 92.0 | 96.6 | 85.7 | 100.0 | 100.0 |
| Cut-off a | 3.84 | 5.24 | 0.26 | 0.15 | See Fig. 2a | See Fig. 2b |
| Logistic regression coefficients | See ‘Results’ and Fig. 2a | See ‘Results’ and Fig. 2b | ||||
| Constant | −6.90 | −7.59 | 11.48 | 1.48 | ||
| Independent variable | 1.79 | 1.45 | −44.12 | −10.09 | ||
| p for the coefficient of the selected independent variable | 0.145 | 0.022 | 0.053 | 0.022 | ||
Se sensitivity, Sp specificity, PPV positive predictive values, NPV negative predictive values
° mmol/mol creatinine
aCut-off values were obtained by logistic regression coefficients