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. Author manuscript; available in PMC: 2013 Feb 18.
Published in final edited form as: Proteomics. 2010 Nov 2;10(22):4128–4141. doi: 10.1002/pmic.201000354

Fig. 4. The spliceosomal cycle.

Fig. 4

The pre-mRNA is shown in black, and the location of the branch site is marked by an A. The exons are shown as solid rectangles and the intron is drawn as a thin line. The spliceosomal complexes and snRNPs are shown in gray. The identity of each spliceosomal complex and snRNP particle is shown. The main steps of spliceosomal cycle, assembly, catalysis, disassembly and recycling are marked on the graph. The main proofreading steps of spliceosomal cycle are marked by clock signs and the main RNA helicases involved in each conformational rearrangement are indicated. The snRNAs within each spliceosomal complex are shown.