Relationship between VLDL-TG secretion rate and intrahepatic triglyceride content (IHTG) in subjects with normal IHTG (triglyceride content <5.6% of liver volume) and nonalcoholic fatty liver disease (NAFLD) (triglyceride content >10% of liver volume). (Adapted from: Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 2008;134:424–431).