Mean ± standard deviation of (A) epithelial cell area, (B) apical epithelial cell density, (C) epithelial percent loss, and (D) cells lost per field. In comparison with the UT group, the 5D group has a smaller cell area, higher apical density, higher percent loss, and more cells lost per field. The 5D + doxycycline 0.025% group showed a rescue for each of these parameters from the 5D values to the UT values, whereas the vehicle alone had no significant effect. The low-dose doxycycline had less of an effect.