Table 3A.

KEGG molecular pathway enrichment analysis of gene expression changes from control P53 versus 1200 μg/kg BW B(a)P-exposed offspring heart tissue transcriptome data set.

KEGG enriched pathway	Observed [O]	Expected [E]	Enrichment [R] = [O]/[E]	Raw p-value	BH adjusted p-value
PPAR signaling pathway	6	0.40	14.88	3.31E–06	1.00E–04
Renin-angiotensin system	2	0.11	18.35	5.30E–03	2.13E–02
Hematopoietic cell lineage	5	0.42	11.91	6.58E–05	1.10E–03
Drug metabolism by CYPP450	4	0.45	8.84	1.10E–03	9.40E–03
Tight junction	5	0.73	6.85	9.00E–04	9.40E–03
Cell adhesion molecules-CAMs	5	0.86	5.84	1.70E–03	1.16E–02
Primary bile acid biosynthesis	2	0.08	24.46	3.00E–03	1.70E–02
Retinol metabolism	3	0.38	7.98	6.40E–03	2.13E–02
Metabolism of xenobiotics by CYPP450	3	0.39	7.75	6.90E–03	2.13E–02

Enrichment analysis from control P 53 versus 1200 μg/kg BW transcriptome data set. Column 1 – Significantly enriched KEGG pathway. Column 2 – Enrichment ratio (R) derived by ratio of significantly altered genes mapping to the pathway versus expected number of genes mapping to pathway form a reference baseline database. Column 3 – raw enrichment p-value of hypergeometic test for enrichment. Column 4 – Benjamini and Hochburg adjusted p-value to correct for multiple testing.