Figure 3.
Synergistic effects of metformin and resveratrol-HMB on insulin sensitivity in mice. Effects of standard dose, low-dose, and very low-dose of metformin compared with low-dose metformin-resveratrol-CaHMB and with very low-dose metformin-resveratrol-CaHMB on (A) plasma insulin and (B) HOMAIR in db/db mice.
Notes: Data are expressed as the mean ± standard error of the mean (n = 10). Bars with the same letter superscripts are not significantly different from each other; bars with nonmatching letter superscripts indicate significant differences between groups (P < 0.025).
Abbreviations: HOMA, homeostatic assessment of insulin resistance; HMB, hydroxymethylbutyrate; MET, metformin; RESV, resveratrol.