Table 1.

Comparison of paired drugs

n	Paired couples	TJSI	AJI	RCT
1	Acyclovir vs doscarnet	+	+	+
2	Buprenorphine vs alfentanil	+
3	Captopril vs moexipril	+	+	+
4	Diltiazem vs felodipine	+	+
5	Enalapril vs Perindopril	+	+	+
6	Fluoxetine vs maprotiline	+	+	+
7	Gemfibrozil vs fenofibrate	+
8	Lovastatin vs fluvastatin	+	+
9	Omeprazole vs lansoprazole	+	+
10	Zidovudine vs abacavir	+	+
Distinguishability from random chance		100%	80%	40%
95% Cl		69%–100%	44%–98%	12%–74%

Note: Plus indicates when the index for the breakthrough drug was higher than that of the compared drug in a couple.

Abbreviations: Cl, confidence interval; TJSI, Top Journals Selectivity Index; AJI, All Journals Index; RCT, randomized controlled trials.