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. Author manuscript; available in PMC: 2013 Feb 18.
Published in final edited form as: Vision Res. 2009 Aug 22;50(7):652–664. doi: 10.1016/j.visres.2009.08.018

Fig. 2.

Fig. 2

Transmission electron microscopy of the RPE-Bruch membrane-choriocapillaris of mice exposed to air (A) or cigarette smoke (B–D). (A) The RPE has normal cytoplasm and regular basal infoldings (BI) Bruch membrane (BrM) is unthickened and without deposits. The choriocapillaris (CC) has regular fenestrations. (B) A membranous vacuole (V) appears in the cytoplasm and the basal infoldings (BI) are fewer and dilated in the RPE. A small outer collagenous layer (OCL) deposit is seen in Bruch membrane. (C and D) More severe membranous vacuoles appear in the cytoplasm than in B. The basal infoldings are fewer and dilated. The choriocapillaris fenestrations are fewer (arrows). (D) The RPE has multiple, large vacuoles in the cytoplasm and the basal infoldings are fewer and dilated, or absent. Thin basal laminar deposits (*) are seen where the basal infoldings are absent. Bar = 500 n.m