Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Diagram of Nrf2 signaling response. Without oxidative stress, Keap1 keeps Nrf2 sequestered in the cytoplasm. Upon oxidative stress (ROS), Nrf2 translocates to the nucleus where it binds to the anti-oxidant response elements (ARE) along with MAF proteins to activate transcription of cytoprotective enyzymes.
