Figure 1. The PKD1L3/TRPP3 complex functions as an acid-sensing ion channel.

(a) Whole-cell current induced by citric acid (pH 2.8, red bar) in oocytes expressing the indicated subunit(s). Holding potential (HP)=−60 mV. (b) Bar graph comparing acid-induced currents in oocytes expressing the indicated subunit(s). HP=−80 mV. Results are shown as mean and standard deviation (SD). n=number of oocytes. (c) Representative acid-induced whole-oocyte currents (upper panel) conducted by PKD1L3/TRPP3 channels under voltage-clamp between −80 to +60 mV (lower panel). (d) I–V curve extracted from c.

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