. Author manuscript; available in PMC: 2013 Jun 4.

Published in final edited form as: Nat Commun. 2012;3:1252. doi: 10.1038/ncomms2257

Table 1.

Permeability ratios of WT PKD1L3/TRPP3 and the listed mutant channels for dimethylamine⁺, trimethylamine⁺, and Mg²⁺.

	Dimethylamine⁺		Trimethylamine⁺		Mg²⁺
Channel type	ΔE_rev ± SD (n)	P_{dimethylamine}/P_Na	ΔE_rev ± SD (n)	P_{trimethylamine}/P_Na	Δ_Erev ± SD (n)	P_Mg/P_Na
Wild Type	−23.6 ± 5.3 (55)	0.39	−46.6 ± 8.4 (54)	0.16	−5.4 ± 3.7 (49)	0.65
TRPP3_D523Q	−8.1 ± 4.1 (8)	0.73	−16.6 ± 8.9 (9)	0.52	−23.1 ± 9.1 (8)	0.27
TRPP3_D525K	−12.2 ± 6.9 (11)	0.62	−13 ± 4.7 (10)	0.60	−12.6 ± 9.1 (9)	0.45
PKD1L3_T2067D	−4.8 ± 1.2 (10)	0.83	−16.3 ± 4.6 (8)	0.53	13.2 ± 5.4 (11)	1.91
PKD1L3_T2067P	−2.2 ± 0.8 (7)	0.92	−9.7 ± 2.9 (7)	0.68	−25.2 ± 4.8 (10)	0.24
PKD1L3_K2069D	−4 ± 0.7 (7)	0.85	−13.8 ± 2.2 (7)	0.58	22.6 ± 0.8 (6)	3.46
PKD1L3_E2072A	−26.8 ± 2.7 (7)	0..35	−51.4 ± 9 (6)	0.13	−15.5 ± 1.2 (7)	0.39

ΔE_rev is the change of reversal potential upon switching the bath solution from Na⁺ to the test ions (ΔE_rev = E_rev,X − E_rev,Na). Statistical comparisons are given in Fig 1. Results are shown as mean and standard deviation (SD). n = number of measurements.