Table 1.
Clinical characteristics of study subjects by Mt5178 C/A genotype
| |
Mt5178C |
Mt5178A |
Pvalue |
|---|---|---|---|
| N = 239 | N = 155 | ||
| Age (years) |
54.3 ± 7.8 |
53.2 ± 7.8 |
0.171 |
| Body mass index (kg/m2) |
23.3 ± 2.8 |
23.5 ± 2.6 |
0.461 |
| Systolic blood pressure (mmHg) |
125.8 ± 15.9 |
125.7 ± 14.1 |
0.940 |
| Diastolic blood pressure (mmHg) |
74.0 ± 10.7 |
73.8 ± 9.1 |
0.823 |
| Serum total cholesterol (mg/dl) |
203.5 ± 34.3 |
202.1 ± 31.8 |
0.672 |
| Serum HDL cholesterol (mg/dl) |
54.6 ± 13.6 |
56.3 ± 16.2 |
0.269 |
| Serum triglyceride (mg/dl) |
136.7 ± 91.1 |
139.5 ± 90.8 |
0.766 |
| Fasting plasma glucose (mg/dl) |
97.2 ± 9.4 |
97.6 ± 9.7 |
0.672 |
| Serum uric acid (mg/dl) |
5.98 ± 1.21 |
5.93 ± 1.21 |
0.673 |
| Blood urea nitrogen (mg/dl) |
15.8 ± 3.7 |
15.2 ± 3.4 |
0.143 |
| Serum creatinine (mg/dl) |
0.817 ± 0.117 |
0.797 ± 0.111 |
0.090 |
| eGFR (ml/min/1.73 m2) |
79.1 ± 13.1 |
81.5 ± 12.4 |
0.066 |
| Renal function (eGFR ≥ 90/90 > eGFR ≥ 60/eGFR < 60) (%) |
17.6/77.8/4.6 |
25.2/72.2/2.6 |
0.133 |
| Antihypertensive medications (%) |
18.8 |
12.9 |
0.122 |
| Alcohol consumption (daily drinkers/occasional drinkers/non-drinkers) (%) |
46.4/35.2/18.4 |
47.7/38.7/13.6 |
0.426 |
| Smoking status (never- or ex-/1–20 cigarettes per day/>20 cigarettes per day) (%) |
59.4/29.7/10.9 |
59.4/25.8/14.8 |
0.429 |
| Coffee consumption (≤1 cup per day/2–3 cups per day/≥4 cups per day) (%) | 61.1/29.7/9.2 | 55.5/32.9/11.6 | 0.510 |
HDL; high-density lipoprotein. eGFR; estimated glomerular filtration rate. Age, body mass index, systolic blood pressure, diastolic blood pressure, serum total cholesterol levels, serum HDL cholesterol levels, serum triglyceride levels, fasting plasma glucose levels, serum uric acid levels, blood urea nitrogen levels, serum creatinine levels and eGFR are given as means ± S.D. For renal function, antihypertensive medications, alcohol consumption, smoking status, and coffee consumption, P values were calculated by chi-squared test. All P values indicate the significance of differences between Mt5178C and Mt5178A.