Table 3.
Odds ratios (ORs) and 95% confidence intervals (CIs) for decreased eGFR (< 90 ml/min/1.73 m2) by Mt5178 C/A genotype and alcohol consumption
| Genotype and alcohol consumption |
Frequency (%) |
OR (95% CI) | Adjusted OR† (95% CI) | Adjusted OR‡ (95% CI) | |
|---|---|---|---|---|---|
| eGFR ≥ 90 ml/min/1.73 m2 | eGFR < 90 ml/min/1.73 m2 | ||||
| Mt5178C (N = 239) |
|
|
|
|
|
| Non-drinkers |
6 (13.6) |
38 (86.4) |
1 (reference) |
1 (reference) |
1 (reference) |
| Occasional drinkers |
20 (23.8) |
64 (76.2) |
0.505 (0.186–1.369) |
0.633 (0.222–1.810) |
0.786 (0.261–2.372) |
| Daily drinkers |
16 (14.4) |
95 (85.6) |
0.938 (0.341–2.576) |
1.038 (0.359–2.999) |
1.024 (0.339–3.092) |
| |
|
|
P for trend = 0.690 |
P for trend = 0.587 |
P for trend = 0.587 |
| Mt5178A (N = 155) |
|
|
|
|
|
| Non-drinkers |
1 (4.8) |
20 (95.2) |
1 (reference) |
1 (reference) |
1 (reference) |
| Occasional drinkers |
12 (20.0) |
48 (80.0) |
0.200 (0.024–1.642) |
0.276 (0.032–2.395) |
0.280 (0.031–2.505) |
| Daily drinkers |
26 (35.1) |
48 (64.9) |
0.092 (0.012–0.727)* |
0.098 (0.012–0.784)* |
0.091 (0.011–0.747)* |
| P for trend = 0.003 | P for trend = 0.004 | P for trend = 0.004 | |||
eGFR; estimated glomerular filtration rate. †OR adjusted for age and body mass index. ‡OR adjusted for age, body mass index, habitual smoking, coffee consumption and antihypertensive medication. *P < 0.05.