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Histochemical examination of collagen-induced arthritis in CA1-Tg mice. Tissue structures of the paw (A-D), knee (E-H), ankle (I-L) and sacroiliac joints (M-P) were examined using histochemistry. Synovial hyperplasia and inflammation, cartilage destruction and bone resorption with pannus formation were detected in the arthritic joints of CA1-Tg mice (n = 5). The single arrow indicates the synovial membrane, and the double arrow indicates the joint cartilage. Magnification: ×400.
