Table 2.
Abundance modified proteins in GCMN
| Identified proteins | Cancer implication | Accession number1 | p-Value | Fold-change | GeneID2 |
|---|---|---|---|---|---|
|
Post-translational modification, protein turnover, chaperones (15) | |||||
| CTSD cathepsin D - |
breast [52] ovarian [53] melanoma [14,15] |
IPI00011229 |
0.024 |
6.8 |
1509 |
| HSP90AA1 heat shock protein 90-kDa alpha (cytosolic), class A member 1 isoform 1 |
|
IPI00382470 |
0.02 |
3.4 |
3320 |
| HSP90AB1 heat shock protein HSP 90-beta |
|
IPI00414676 |
0.013 |
3.6 |
3326 |
| HSPA1A;HSPA1B heat shock 70-kDa protein 1 |
|
IPI00304925 |
0.031 |
2.4 |
3303 |
| HSPA8 Isoform 1 of heat shock cognate 71-kDa protein |
|
IPI00003865 |
0.0016 |
5.2 |
3312 |
| HSPB1 heat shock protein beta-1 |
|
IPI00025512 |
0.0027 |
3.8 |
3315 |
| PDIA3 protein disulfide-isomerase A3 |
ovarian [54] |
IPI00025252 |
0.012 |
5.4 |
2923 |
| PHB prohibitin |
gastric carcinoma [28], thyroid cancer [29], hepatocellular carcinoma [30], melanoma [16,17] |
IPI00017334 |
0.025 |
5.3 |
5245 |
| PSMB1 proteasome subunit beta type-1 |
|
IPI00025019 |
0.045 |
3.5 |
5689 |
| SFN Isoform 1 of 14-3-3 protein sigma |
|
IPI00013890 |
0.027 |
1.7 |
2810 |
| YWHAB long isoform of 14-3-3beta/alpha |
|
IPI00216318 |
0.0012 |
2.2 |
7529 |
| YWHAE 14-3-3epsilon |
|
IPI00000816 |
0.0051 |
4.2 |
7531 |
| YWHAG 14-3-3gamma |
|
IPI00220642 |
0.024 |
2.1 |
7532 |
| YWHAQ 14-3-3theta |
|
IPI00018146 |
0.00088 |
3.3 |
10971 |
| YWHAZ 14-3-3zeta/delta |
|
IPI00021263 |
0.0021 |
2.6 |
7534 |
|
Cytoskeleton (4) | |||||
| CAPZA1 F-actin-capping protein subunit alpha-1 |
|
IPI00005969 |
0.0044 |
2.6 |
829 |
| CAPZB cDNA, FLJ93598, highly similar to Homo sapiens capping protein (actin filament) muscle Z-line, beta |
|
IPI00641107 |
0.017 |
2.9 |
832 |
| Isoform 2 of dynein heavy chain 2, axonemal |
|
IPI00651691 |
0.004 |
2.3 |
146754 |
| Isoform 2 of myosin light chain kinase, smooth muscle |
|
IPI00221255 |
0.0018 |
2.6 |
4638 |
|
General function prediction only (5) | |||||
| CDC42 Isoform 2 of cell-division control protein 42 homolog |
immune escape of cancer [55] |
IPI00016786 |
0.017 |
2.8 |
998 |
| CSPG4 chondroitin sulfate proteoglycan 4 |
melanoma, human carcinoma, sarcoma [18] |
IPI00019157 |
0.026 |
2.3 |
1464 |
| HNRNPA2B1 isoform B1 of heterogeneous nuclear ribonucleoproteins A2/B1 |
glioblastoma[56] lung cancer [57] |
IPI00396378 |
0.015 |
4.9 |
3181 |
| PEBP1 phosphatidylethanolamine-binding protein 1 |
prostate [58], breast [59], gastrointestinal stromal [60], melanoma [19], ovarian [61] |
IPI00219446 |
0.026 |
2.9 |
5037 |
| RAC1 isoform A of Ras-related C3 botulinum toxin substrate 1 |
skin tumor [62] |
IPI00010271 |
0.0092 |
3.7 |
5879 |
|
Carbohydrate transport and metabolism (3) | |||||
| ALDOA fructose-bisphosphate aldolase A |
|
IPI00465439 |
0.034 |
4 |
226 |
| Uncharacterized protein ENSP00000348237 |
|
IPI00453476 |
0.0012 |
3.1 |
|
| FLG2 filaggrin-2 |
|
IPI00397801 |
0.000021 |
0.2 |
388698 |
|
Energy production and conversion (2) | |||||
| ATP5B ATP synthase subunit beta, mitochondrial |
|
IPI00303476 |
0.032 |
5 |
506 |
| ETFA electron transfer flavoprotein subunit alpha, mitochondrial |
|
IPI00010810 |
0.0028 |
3.4 |
2108 |
|
Signal transduction mechanisms (3) | |||||
| ARHGDIA rho GDP-dissociation inhibitor 1 |
mesothelioma [63] |
IPI00003815 |
0.047 |
3.4 |
396 |
| FBLN5 fibulin-5 |
breast cancer [64] |
IPI00294615 |
0.0028 |
3.4 |
10516 |
| RYR3 uncharacterized protein RYR3 |
|
IPI00217185 |
0.013 |
2.7 |
6263 |
|
Intracellular trafficking, secretion, and vesicular transport (3) | |||||
| ANXA1 annexin A1 |
breast cancer [65] |
IPI00218918 |
0.03 |
3 |
301 |
| ANXA2 annexin A2 isoform 1 |
breast cancer [66] |
IPI00418169 |
0.0059 |
1.8 |
302 |
| ANXA5 annexin A5 |
colorectal cancer [67] |
IPI00329801 |
0.025 |
3.8 |
308 |
|
Amino acid transport and metabolism (2) | |||||
| PHGDH D-3-phosphoglycerate dehydrogenase |
breast cancer [68] |
IPI00011200 |
0.031 |
5 |
26227 |
| TPSB2 TPSB2 |
|
IPI00419942 |
0.043 |
2.2 |
64499 |
|
Lipid transport and metabolism (2) | |||||
| ECH1 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrial |
|
IPI00011416 |
0.00034 |
3.1 |
1891 |
| FASN fatty acid synthase |
breast cancer, endometrial cancer [69] prostate cancer [70] |
IPI00026781 |
0.023 |
3.1 |
2194 |
|
Translation, ribosomal structure, and biogenesis (2) | |||||
| EEF1A1 elongation factor 1-alpha 1 |
|
IPI00396485 |
0.012 |
2.5 |
1915 |
| RPSA ribosomal protein SA, 33-kDa protein |
melanoma [20] |
IPI00413108 |
0.024 |
2.9 |
3921 |
|
RNA processing and modification (1) | |||||
| HNRNPU short isoform of heterogeneous nuclear ribonucleoprotein U |
|
IPI00479217 |
0.0037 |
2.3 |
3192 |
|
Cell cycle control, cell division, chromosome partitioning (1) | |||||
| KRT1 keratin, type II cytoskeletal 1 |
|
IPI00220327 |
0.016 |
0.7 |
3848 |
|
Inorganic ion transport and metabolism (1) | |||||
| CLIC1 chloride intracellular channel protein 1 |
|
IPI00010896 |
0.015 |
3.5 |
1192 |
|
Secondary metabolites biosynthesis, transport, and catabolism (1) | |||||
| ADH1B alcohol dehydrogenase 1B |
|
IPI00473031 |
0.025 |
0.2 |
125 |
|
Function unknown (1) | |||||
| HRNR hornerin | IPI00398625 | 0.035 | 0.2 | 388697 | |
Accession Number1: International Protein Index (IPI) accession number, GeneID2: NCBI GeneID.