Skip to main content
. 2013 Feb 18;8(2):e56317. doi: 10.1371/journal.pone.0056317

Figure 5. GLV-1h68-induced accumulation of intratumoral PFC is also detectable in lung carcinomas and breast adenocarcinomas.

Figure 5

(A–D) 1H/19F overlay and 1H T2 images of mock-infected (A, B) and GLV-1h68-infected (C, D) A549 lung carcinoma-bearing mice were analyzed 7 dpi by in vivo 19F MRI (PFC, 4 dpi). (E) quantitative evaluation of the 19FTWR of in vivo 19F MRI measurements of mock-infected and GLV-1h68-treated A549 tumors at 7 dpi revealed a detectable 19FTWR only in VACV-treated tumors (n = 4). (F–H) mock-infected (F) and GLV-1h68-infected (G) GI-101A breast adenocarcinoma-bearing mice were analyzed 10 dpi by ex vivo 19F MRI (PFC injection, 7 dpi). (H) quantitative evaluation of the 19FTWR of ex vivo 19F MRI measurements of mock-infected and GLV-1h68-treated GI-101A tumors at 10 dpi revealed a significant difference between both groups (n = 4–5; p = 0.033). Shown are the mean values +/− standard deviations. The signal intensity of all presented 19F images was scaled to SNR = 30. Asterisk indicate a significant difference between experimental groups (n.d. = not detectable; *p<0.05; Students t test). All images are representative examples.