Figure 2. Comparative evaluation of the somatic mutations between primary and model tumors.

(A) The cumulative distribution of the somatic mutations identified on the targeted exons of the four patients’ primary tumors (P) as well as tumor models (N: Neurospheres, C: Cell culture, X: Xenograft) is reported as a function of their class and predicted protein changes. The mutations were identified after excluding mouse reads from patients’ SK00102 and SK00072 data. (B) A statistical comparison of the somatic mutations called between primary and model identifies shared mutations at constant mutant allele frequencies (black), shared mutations with changing mutant allele frequency (red) as well mutations specific to the primary (green) or the tumor model (blue). (C–F) Mutant Allele frequency differences between the primary tumor (x axis) and the model tumor (y axis) of patient SK01600 (C), SK00115 (D), SK00102 (E), SK00072 (F) at all positions identified as somatically mutated in either sample and covered by ≥30 reads. Mutations are classified as shared with constant frequency (black), with changing frequencies (red), specific to the primary tumor (green) or to the tumor model (blue).