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. 2013 Feb 18;8(2):e56316. doi: 10.1371/journal.pone.0056316

Figure 3. Effects of conditional p38α deletion on anti-GBM nephritis.

Figure 3

(A) p38MAPKα deletion is depending on tissue and reaches from 50–100%. (B) Western blot experiments reveal significant reduction of p38 phosphorylation in kidneys of MxCre-p38αΔ/Δ transgenic mice at day 14 after induction of anti-GBM nephritis. Downstream activation of MK2 is also strongly reduced. Three representative animals are shown in each group. (C) Survival of wild type and MxCre-p38αΔ/Δ mice during anti-GBM nephritis shows no difference (controls n = 10, continuous line; wild type n = 16, spotted line; MxCre-p38αΔ/Δ mice n = 18, dashed line). (D) Serum urea levels in wild-type (day 14: mean 66.61±18.33 mg/dl; n = 9) and MxCre-p38αΔ/Δ mice (day 14: mean 58.43±10.46 mg/dl, p = ns vs. wild-type; n = 9). (E) Creatinine clearance decreases in both wild type (134.4±29.70; n = 8) and MxCre-p38αΔ/Δ (97.79±16.15; n = 8) mice.