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. 2013 Feb 18;8(2):e55714. doi: 10.1371/journal.pone.0055714

Figure 4. The knockdown of osteopontin, LAMB3 and ITGB1 in SPC-A-1 sci cells inhibits metastasis in vivo.

Figure 4

Representative histological images of mouse lungs inspected for the presence of microscopic lesions (20×, upper; 400×, lower) ten weeks after tail-vein injections with SPC-A-1sci cells stably expressing shRNAs against the negative control (shRNA-NC, left 1), osteopontin (shRNA-osteopontin; left 2), Laminin β3 (shRNA-LAMB3, right 2), and Integrin β1 (shRNA-ITGB1, right 1).