Figure 4. Putative biding sites at the promoter region of each of the six genes (CDH2, FN1, CITED2, MKI67, CTNNB1 and CTNNA3) and the known consensus Grh binding motifs. A).

Genomic regions identified to be putative binding sites of GRHL2, using the hg19 build 37 of the human genome. Cross-species conserved regions are highlighted in yellow and are demonstrated in Fig. S2. B) Visualization of the position weight matrices of the reverse-complementary DNA sequence motifs of Grainyhead (Grh) factors (TRANSFAC database [43]).