Figure 6. Role of classical NF-κB pathway activation in BCL2A1 induction mediated by IL-17A.

(A) Nuclear translocation of the NF-κB subunit p65/RelA in DC, after 1 h of IL-17A treatment. Right panels are zoomed views of the left panels, representative of n = 3 donors. Scale bars, 10 µm. (B) Effect of the classical NF-κB pathway inhibitor Bay-11-7085 on BCL2A1 mRNA levels measured by real-time PCR, 48 h after cytokine treatment. The relative gene expression is compared with either TBP or GAPDH.