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. 2013 Feb 18;8(2):e56520. doi: 10.1371/journal.pone.0056520

Figure 2. Diap3-overexpressing mice retain otoacoustic emissions at 24 weeks of age.

Figure 2

Mean DPOAE levels at 12 kHz and 24 kHz (and mean ± SEM) are shown. Statistical significance was determined by repeated measures ANOVA. (A–B) Results for line 771 mice (filled circles, n = 6) and wild-type littermates (open circles, n = 3). (A) At 12 kHz, there was no significant difference in responses between line 771 mice and wild-type littermates, suggesting that OHC function is preserved. (B) At 24 kHz, the difference in DPOAE levels was statistically significant, indicating a loss of OHC function. (C–D) Results for line 924 (filled triangles, n = 5) and wild-type littermates (open triangles, n = 4). (C) DPOAE levels at 12 kHz were indistinguishable from those of wild-type littermates indicative of preserved OHC function. (D) At 24 kHz, although the differences were not statistically significant, there was clear inter-animal variation among the line 924 mice.